Interior Minister Rehman Malik told the BBC the Taliban would not be allowed to take advantage of the crisis to increase its support.
The UN has said it has now raised nearly half of the $460m (£294m) it needs for initial relief efforts.
Meanwhile new flood warnings have been issued in some areas of Pakistan.
The authorities say as many as 20 million people are affected by the floods. The UN says six million desperately need emergency aid but most still have not received it. Ten of thousands of villages remain under water.
There are growing health concerns for those surviving without proper shelter, food or clean drinking water, three weeks after the country's worst natural disaster in modern times began.
Overwhelmed
Survivors have criticised the government's response to the disaster, saying aid has been too slow to arrive and there are increasing reports of victims staging protests to demand help from the government.
Mr Malik said he was satisfied that the government had coped with the initial response but that it had been overwhelmed by the scale of the crisis.
"What happened was never expected. In the history of the whole subcontinent there was never such a disaster," he said.
Mr Malik said he was aware of the danger that the Taliban could increase its foothold in flood-hit areas by taking on charitable roles and winning support from survivors.
But he said this would not be allowed to happen and blamed the concerns on internal "party politics".
The US ambassador to Pakistan, Anne Patterson, also played down the fears, saying stories that extremists groups were the only organisations involved in relief work in some areas were "greatly exaggerated".
The UK's International Development Minister, Andrew Mitchell, who has been visiting north-west Pakistan, said he felt the Pakistani relief teams were doing well in getting supplies to many of the victims, in the face of great difficulties.
US Senator John Kerry, the head of the Senate Foreign Relations Committee, is also due in Pakistan to view relief efforts.
Pakistani President Asif Ali Zardari is travelling to Russia for a regional summit, but is only expected to stay for a few hours. Mr Zardari was criticised after not returning home from a trip to Europe earlier this month to deal with the growing crisis.
'Never expected'
There have been fresh flood warnings, with a series of towns in north-west Sindh, close to the border with Baluchistan, placed on high alert. Rising floodwaters, carried by the River Indus, are travelling south and are expected to hit the region soon.
UN officials say the floods are now covering an area the size of England. At least 1,600 people have been killed, with health officials warning the toll could rise as water-borne diseases spread.
Aid agencies say six million people are in need of immediate assistance but many have received no aid at all.
The distribution of supplies has been hampered by severe damage to the country's infrastructure, with roads and bridges washed away or blocked by landslides.
The UN has been struggling to raise the money it says is urgently needed for the immediate relief effort.
UN spokesman Maurizio Giuliano told Reuters news agency there had "been an improvement" in donations, but he added: "The challenges are absolutely massive and the floods are not over."
Unicef, the UN's children's fund, called for "an urgent effort" from donors.
"Two million dollars are needed every day to provide water - this is not sustainable. We don't have two million dollars a day," said Unicef's regional director, Daniel Toole.
As well as buildings, large areas of crops and farmland have been washed away, leading to fears of food insecurity in the future.
"If immediate steps are not taken, we fear a famine," said Mian Iftikhar Hussain, a provincial information minister in north-west Pakistan.
"The farmers have lost everything: their crops, their machines, their houses, their seeds."
The World Bank has said it is redirecting $900m in existing loans to Pakistan to flood relief and recovery.
Pakistani officials have said it could take five years and up to $15bn for the country to recover.
BBC Urdu will transmit six daily bulletins in Urdu and Pashto providing vital information including how to stay safe, avoid disease and access aid. Special programmes will be broadcast each day in Urdu at 12.30, 15.30 and 18.30 and in Pashto at 12.45, 15.45 and 18.45 (local times).
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